Defb21 Gene Summary [Rat]
Predicted to enable lipopolysaccharide binding activity and membrane destabilizing activity. Predicted to be involved in several processes, including defense response to other organism; killing of cells of another organism; and negative regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in extracellular region. Orthologous to human DEFB118 (defensin beta 118). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Defb21 |
| Official Name | defensin beta 21 [Source:RGD Symbol;Acc:1562393] |
| Ensembl ID | ENSRNOG00000023154 |
| Bio databases IDs | |
| Aliases | defensin beta 21 |
| Synonyms | C20orf63, DEFB-18, Defb21, defensin beta 118, defensin beta 21, defensin β 118, defensin β 21, ESC42, ESP13.6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Defb21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Beta defensin
- protein binding
- lipopolysaccharide binding
Pathways
Biological processes and signaling networks where the Defb21 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Defb21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- defense response to Gram-negative bacterium
- innate immune response
- negative regulation of cell adhesion
- spermatogenesis
- killing of cells of other organism
- defense response to bacterium
- defense response to Gram-positive bacterium
- negative regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- lipopolysaccharide binding