CA6 Gene Summary [Human]
The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CA6 |
| Official Name | carbonic anhydrase 6 [Source:HGNC Symbol;Acc:HGNC:1380] |
| Ensembl ID | ENSG00000131686 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 6 |
| Synonyms | CAR6, Carbonic anhydrase 6, CA-VI, DOC1, GUSTIN |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CA6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- breast cancer
- osteoporosis
- acne vulgaris
- heart failure
- hypertension
- epilepsy
- hypoxia
- schizophrenia
- controlled hypertension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CA6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of chemical stimulus involved in sensory perception of bitter taste
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- carbonate dehydratase activity