Car6 Gene Summary [Mouse]
Predicted to enable carbonate dehydratase activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of bitter taste. Located in cytosol and extracellular space. Is expressed in brain; inner ear; submandibular gland; and trunk. Orthologous to human CA6 (carbonic anhydrase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Car6 |
| Official Name | carbonic anhydrase 6 [Source:MGI Symbol;Acc:MGI:1333786] |
| Ensembl ID | ENSMUSG00000028972 |
| Bio databases IDs | |
| Aliases | carbonic anhydrase 6 |
| Synonyms | CAR6, Carbonic anhydrase 6, CA-VI, DOC1, GUSTIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Car6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- carbonate dehydratase
- Eukaryotic-type carbonic anhydrase
- alpha_CA
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- essential hypertension
- breast cancer
- osteoporosis
- acne vulgaris
- heart failure
- hypertension
- epilepsy
- hypoxia
- schizophrenia
- controlled hypertension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical compartment
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Car6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- detection of chemical stimulus involved in sensory perception of bitter taste
- one-carbon metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- carbonate dehydratase activity