IMPA1 Gene Summary [Human]
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Dec 2014]
Details
| Type | Protein Coding |
| Official Symbol | IMPA1 |
| Official Name | inositol monophosphatase 1 [Source:HGNC Symbol;Acc:HGNC:6050] |
| Ensembl ID | ENSG00000133731 |
| Bio databases IDs | |
| Aliases | inositol monophosphatase 1, myo-inositol monophosphatase 1 |
| Synonyms | 2610002K09Rik, 2900059K10RIK, IMP, IMPA, Impa1-L, inositol monophosphatase 1, inositol (myo)-1(or 4)-monophosphatase 1, MRT59, Myoinositol 1 (or 4)-monophosphatase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IMPA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatase
- metal ion binding
- protein homodimerization
- inositol-1(or 4)-monophosphatase
- 3'(2'),5'-bisphosphate nucleotidase, bacterial
- protein binding
- Inositol monophosphatase family
- manganese ion binding
- FIG
- magnesium ion binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic lymphocytic leukemia
- autosomal recessive mental retardation type 59
- hypoplasia
- seizures
- Huntington disease
- hyperactive behavior
regulates
- phosphatidylinositol
- CREB
- myo-inositol
- phosphate
role in cell
- growth
- growth in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IMPA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol metabolic process
- signal transduction
- inositol biosynthetic process
- phosphatidylinositol phosphorylation
- phosphatidylinositol biosynthetic process
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- identical protein binding
- protein binding
- inositol monophosphate 1-phosphatase activity
- protein homodimerization activity
- manganese ion binding
- inositol monophosphate phosphatase activity
- lithium ion binding
- inositol monophosphate 3-phosphatase activity
- inositol monophosphate 4-phosphatase activity