SUMO3 Gene Summary [Human]
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]
Details
| Type | Protein Coding |
| Official Symbol | SUMO3 |
| Official Name | small ubiquitin like modifier 3 [Source:HGNC Symbol;Acc:HGNC:11124] |
| Ensembl ID | ENSG00000184900 |
| Bio databases IDs | |
| Aliases | small ubiquitin like modifier 3 |
| Synonyms | 2810014B19Rik, AA409334, D10Ertd345e, small ubiquitin-like modifier 3, SMT3A, Smt3B, SMT3H1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SUMO3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ubiquitin family
- Ubl1_cv_Nsp3_N-like
- Ubiquitin homologues
- protein binding
- surface domain
Pathways
Biological processes and signaling networks where the SUMO3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- thyroid cancer
- gastric cancer
- breast cancer
- Down syndrome
- hepatocellular dysplasia
- bipolar disorder
- Crohn disease
- asthma
- cardiomyopathy
role in cell
- binding in
- proliferation
- invasion
- expression in
- apoptosis
- phosphorylation in
- activation in
- growth
- generation in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- glutaminergic synapse
- Cytoplasm
- nuclear foci
- sister chromatids
- nucleoplasm
- nucleoli
- nuclear bodies
- XY bodies
- PML nuclear bodies
- mitotic spindle
- kinetochores
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SUMO3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of DNA binding
- protein sumoylation
- regulation of protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- kinetochore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein tag
- small conjugating protein ligase binding