IMPA2 Gene Summary [Human]
This locus encodes an inositol monophosphatase. The encoded protein catalyzes the dephosphoylration of inositol monophosphate and plays an important role in phosphatidylinositol signaling. This locus may be associated with susceptibility to bipolar disorder. [provided by RefSeq, Jan 2011]
Details
| Type | Processed Transcript |
| Official Symbol | IMPA2 |
| Official Name | inositol monophosphatase 2 [Source:HGNC Symbol;Acc:HGNC:6051] |
| Ensembl ID | ENSG00000141401 |
| Bio databases IDs | |
| Aliases | inositol monophosphatase 2, myo-inositol monophosphatase 2 |
| Synonyms | 2210415D20Rik, IMP 2, IMPase 2, inositol monophosphatase 2, Myo-inositol monophosphatase A2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IMPA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatase
- protein homodimerization
- inositol-1(or 4)-monophosphatase
- 3'(2'),5'-bisphosphate nucleotidase, bacterial
- protein binding
- Inositol monophosphatase family
- FIG
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe acute respiratory syndrome
- bipolar disorder
- stroke
- peripheral arterial disease
- androgenic alopecia
- gastric adenocarcinoma
- gastric epithelial cancer
- obsessive-compulsive disorder
- hydronephrosis
- chronic lymphocytic leukemia
role in cell
- expression in
- apoptosis
- paclitaxel sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IMPA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol metabolic process
- inositol biosynthetic process
- signal transduction
- response to lithium ion
- phosphatidylinositol phosphorylation
- phosphate-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- inositol monophosphate 1-phosphatase activity
- protein homodimerization activity
- protein binding
- metal ion binding
- inositol monophosphate 3-phosphatase activity
- inositol monophosphate 4-phosphatase activity