NXF1 Gene Summary [Human]
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NXF1 |
| Official Name | nuclear RNA export factor 1 [Source:HGNC Symbol;Acc:HGNC:8071] |
| Ensembl ID | ENSG00000162231 |
| Bio databases IDs | |
| Aliases | nuclear RNA export factor 1, tip associating protein |
| Synonyms | MEX67, MEX67H, Mvb1, nuclear RNA export factor 1, TAP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NXF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- TAP C-terminal domain
- nuclear export signal
- UBA-like domain
- mRNA binding
- Tap, RNA-binding
- nuclear localization sequence
- Leucine rich repeat
- central domain
- protein binding
- Leucine Rich repeats (2 copies)
- RNA binding
- leucine-rich repeat
- NXT1 binding domain
- NTF2_like
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- pemphigus foliaceus
- infection by HIV-1
role in cell
- replication in
- cell death
- molecular cleavage in
- accumulation in
- assembly in
- alternative splicing in
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- Plasma Membrane
- cytosol
- nuclear pores
- nucleoplasm
- nuclear rim
- nuclear envelope
- nuclear speckles
- apical processes
- detergent-soluble fraction
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NXF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA export from nucleus
- protein transport
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nuclear inclusion body
- nucleus
- cytoplasmic stress granule
- cytoplasm
- nuclear RNA export factor complex
- nuclear speck
- cytosol
- transcription export complex
- nuclear pore
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding