CD180 Gene Summary [Human]
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD180 |
| Official Name | CD180 molecule [Source:HGNC Symbol;Acc:HGNC:6726] |
| Ensembl ID | ENSG00000134061 |
| Bio databases IDs | |
| Aliases | CD180 molecule |
| Synonyms | CD180 antigen, CD180 molecule, F630107B15, LY64, Ly-78, Ly ag 78, RP105 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD180 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- leucine-rich repeat
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat
- Leucine rich repeat C-terminal domain
- protein binding
Pathways
Biological processes and signaling networks where the CD180 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- septic shock
- diabetic nephropathy
- insulin-dependent diabetes mellitus
- idiopathic interstitial pneumonia
- endometriosis
- chronic lymphocytic leukemia
- acute myeloid leukemia
- marginal zone cell lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
role in cell
- expression in
- phosphorylation in
- proliferation
- tyrosine phosphorylation in
- activation in
- production in
- growth
- quantity
- binding in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- nucleoplasm
- nucleoli
- membrane rafts
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD180 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- cellular response to lipopolysaccharide
- innate immune response
- lipopolysaccharide-mediated signaling pathway
- positive regulation of lipopolysaccharide-mediated signaling pathway
- B cell proliferation involved in immune response
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitotic spindle
- extracellular matrix
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding