RSAD2 Gene Summary [Human]
The protein encoded by this gene is an interferon-inducible antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to viral proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including influenza virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]
Details
| Type | Protein Coding |
| Official Symbol | RSAD2 |
| Official Name | radical S-adenosyl methionine domain containing 2 [Source:HGNC Symbol;Acc:HGNC:30908] |
| Ensembl ID | ENSG00000134321 |
| Bio databases IDs | |
| Aliases | radical S-adenosyl methionine domain containing 2, virus-inhibitory protein, endoplasmic reticulum–associated, interferon-inducible |
| Synonyms | 2510004L01Rik, Best5, cig33, cig5, CYTOMEGALOVIRUS INDUCIBLE GENE5, LOC102724141, radical S-adenosyl methionine domain containing 2, SAND, Vig1, Viperin |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RSAD2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Radical_SAM
- binding protein
- 4Fe-4S single cluster domain
- amphipathic helix
- Radical SAM superfamily
- enzyme
- protein binding
- Elongator protein 3, MiaB family, Radical SAM
- antiviral radical SAM protein viperin
Pathways
Biological processes and signaling networks where the RSAD2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- systemic lupus erythematosus
- dermatomyositis
- COVID-19
- idiopathic inflammatory myopathy
- antineutrophil cytoplasmic antibody-associated vasculitis
- diabetes mellitus
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- atherosclerosis
role in cell
- proliferation
- expression in
- activation
- differentiation
- fluidity
- disruption
- ossification by
- binding in
- production in
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- Endoplasmic Reticulum
- Mitochondria
- lipid droplets
- endoplasmic reticulum membrane
- mitochondrial outer membrane
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RSAD2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of protein secretion
- positive regulation of toll-like receptor 9 signaling pathway
- innate immune response
- defense response to virus
- CD4-positive, alpha-beta T cell differentiation
- positive regulation of toll-like receptor 7 signaling pathway
- response to virus
- positive regulation of immune response
- negative regulation of viral genome replication
- CD4-positive, alpha-beta T cell activation
- positive regulation of T-helper 2 cell cytokine production
Cellular Component
Where in the cell the gene product is active
- lipid particle
- endoplasmic reticulum membrane
- mitochondrion
- Golgi apparatus
- endoplasmic reticulum
- mitochondrial outer membrane
- mitochondrial inner membrane
- fibrillar center
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- lyase activity
- 4 iron, 4 sulfur cluster binding