LGALS9 Gene Summary [Human]
The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LGALS9 |
| Official Name | galectin 9 [Source:HGNC Symbol;Acc:HGNC:6570] |
| Ensembl ID | ENSG00000168961 |
| Bio databases IDs | |
| Aliases | galectin 9 |
| Synonyms | gal-9, galectin, galectin-9, HOM-HD-21, HUAT, lectin, galactose binding, soluble 9, LGALS35, LGALS5, LGALS9A, UAT |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LGALS9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-terminal carbohydrate recognition domain
- carbohydrate recognition domain
- enzyme binding
- disaccharide binding
- N-terminal carbohydrate recognition domain
- protein binding
- receptor binding
- galactoside binding
- protein kinase activator
- galactose binding
- receptor agonist activity
- carbohydrate binding
- GLECT
Pathways
Biological processes and signaling networks where the LGALS9 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- chronic lymphocytic leukemia
- colorectal cancer
- hepatic steatosis
- disease-free survival
- eosinophilia
- Sjögren syndrome
- diabetes mellitus
- primary prostate cancer
- survival
role in cell
- maturation
- cell death
- production in
- expression in
- phosphorylation in
- proliferation
- apoptosis
- chemotaxis
- activation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- Nucleus
- cytosol
- apical membrane
- basolateral membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LGALS9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of mast cell degranulation
- inflammatory response
- positive regulation of activated T cell autonomous cell death
- positive regulation of interferon-gamma production
- positive regulation of dendritic cell chemotaxis
- natural killer cell tolerance induction
- positive regulation of tumor necrosis factor production
- negative regulation of interferon-gamma production
- positive regulation of dendritic cell differentiation
- negative regulation of tumor necrosis factor production
- p38MAPK cascade
- negative regulation of chemokine production
- toll-like receptor 4 signaling pathway
- regulation of p38MAPK cascade
- negative regulation of gene expression
- positive regulation of interleukin-8 production
- positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
- positive regulation of gene expression
- regulation of interleukin-5 production
- response to interleukin-1
- regulation of interleukin-4 production
- positive regulation of interleukin-6 production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of interleukin-4 production
- positive regulation of monocyte chemotactic protein-1 production
- toll-like receptor 2 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of viral entry into host cell
- positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
- chemotaxis
- mature dendritic cell differentiation
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
- positive regulation of transforming growth factor beta production
- positive regulation of dendritic cell apoptotic process
- maternal process involved in female pregnancy
- negative regulation of activated T cell proliferation
- female pregnancy
- negative regulation of natural killer cell mediated cytotoxicity
- ERK1 and ERK2 cascade
- positive regulation of interleukin-12 production
- positive regulation of interleukin-13 production
- positive regulation of ERK1 and ERK2 cascade
- response to lipopolysaccharide
- cellular response to interferon-gamma
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- galactoside binding
- carbohydrate binding
- disaccharide binding
- galactose binding
- enzyme binding