IRAK1 Gene Summary [Human]
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IRAK1 |
| Official Name | interleukin 1 receptor associated kinase 1 [Source:HGNC Symbol;Acc:HGNC:6112] |
| Ensembl ID | ENSG00000184216 |
| Bio databases IDs | |
| Aliases | interleukin 1 receptor associated kinase 1 |
| Synonyms | Il1rak, interleukin-1 receptor-associated kinase 1, IRAK, mPLK, pelle, Plk, Plpk, RGD1563841 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRAK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- protein kinase binding
- undetermined domain (from IRAK)
- Protein tyrosine and serine/threonine kinase
- ATP-binding domain
- Pst domain
- heat shock protein binding
- protein binding
- Protein kinase domain
- identical protein binding
- phosphorylation site
- kinase
- kinase domain
- interleukin-1 receptor binding
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- protein homodimerization
- Tyrosine kinase, catalytic domain
- Death Domain Superfamily of protein-protein interaction domains
- death domain binding domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the IRAK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Hepatic Cholestasis
- IL-1 Signaling
- IL-8 Signaling
- iNOS Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- p38 MAPK Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Th17 Activation Pathway
- Toll-like Receptor Signaling
- TREM1 Signaling
- Type I Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- epithelial cancer
- experimental autoimmune encephalomyelitis
- organismal death
- hepatocellular carcinoma
- liver cancer
- psoriasis
- glomerulonephritis
- chronic lymphocytic leukemia
role in cell
- apoptosis
- expression in
- growth
- quantity
- migration
- survival
- phosphorylation in
- colony formation
- invasion by
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- Nucleus
- lipid droplets
- cytosol
- endosomal membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRAK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Toll signaling pathway
- positive regulation of MAP kinase activity
- toll-like receptor 2 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- protein autophosphorylation
- JNK cascade
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of smooth muscle cell proliferation
- cellular response to heat
- MyD88-dependent toll-like receptor signaling pathway
- cellular response to hypoxia
- intracellular signal transduction
- toll-like receptor 9 signaling pathway
- negative regulation of NF-kappaB transcription factor activity
- positive regulation of type I interferon production
- toll-like receptor 4 signaling pathway
- I-kappaB kinase/NF-kappaB cascade
- type I interferon-mediated signaling pathway
- toll-like receptor signaling pathway
- cellular response to lipopolysaccharide
- innate immune response
- response to interleukin-1
- lipopolysaccharide-mediated signaling pathway
- regulation of cytokine-mediated signaling pathway
- interleukin-1-mediated signaling pathway
- response to lipopolysaccharide
Cellular Component
Where in the cell the gene product is active
- lipid particle
- nucleus
- cytoplasm
- cytosol
- endosome membrane
- macromolecular complex
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- heat shock protein binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- protein kinase activity
- protein serine/threonine kinase activity
- kinase activity