VAPA Gene Summary [Human]
The protein encoded by this gene is a type IV membrane protein. It is present in the plasma membrane and intracellular vesicles. It may also be associated with the cytoskeleton. This protein may function in vesicle trafficking, membrane fusion, protein complex assembly and cell motility. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | VAPA |
| Official Name | VAMP associated protein A [Source:HGNC Symbol;Acc:HGNC:12648] |
| Ensembl ID | ENSG00000101558 |
| Bio databases IDs | |
| Aliases | VAMP associated protein A |
| Synonyms | hVAP-33, VAMP-A, VAMP-ASSOCIATED, VAMP associated protein A, VAP-33, vesicle-associated membrane protein, associated protein A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAPA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- ER retention sequence
- binding protein
- transmembrane domain
- protein homodimerization
- coiled-coil domain
- protein domain specific binding
- protein binding
- MSP (Major sperm protein) domain
- identical protein binding
- VAP consensus domain
- protein heterodimerization
Pathways
Biological processes and signaling networks where the VAPA gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- small cell lung cancer
- neonatal late-onset sepsis
- diverticular disease
role in cell
- apoptosis
- cell viability
- formation in
- cell death
- outgrowth
- colony formation by
- fusion
- outgrowth in
- mislocalization in
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- microtubule cytoskeleton
- endoplasmic reticulum mitochondria contact site
- Cytoplasm
- perinuclear region
- membrane surface
- cellular membrane
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- microtubules
- cell-cell contacts
- secretory granule membrane
- cytosol
- endoplasmic reticulum membrane
- cisternae
- apical membrane
- outer leaflet
- Golgi membrane
- lysosome membrane
- nuclear envelope
- cytoplasmic vesicles
- rough endoplasmatic reticulum
- peroxisomes
- tight junctions
- microsomal membrane
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAPA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fusion
- COPII-coated vesicle budding
- neuron projection development
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- endoplasmic reticulum organization
- sphingomyelin biosynthetic process
- ER to Golgi vesicle-mediated transport
- release of virus from host
- sterol transport
- phospholipid transport
- protein localization in endoplasmic reticulum
- ceramide transport
- cholesterol transport
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- endoplasmic reticulum
- Golgi membrane
- plasma membrane
- endoplasmic reticulum membrane
- tight junction
- nuclear membrane
- perinuclear region of cytoplasm
- cytosol
- vesicle
- endoplasmic reticulum exit site
- azurophil granule membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- protein homodimerization activity
- protein heterodimerization activity
- cadherin binding
- microtubule binding
- FFAT motif binding