IRF3 Gene Summary [Human]
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
Details
| Type | Processed Transcript |
| Official Symbol | IRF3 |
| Official Name | interferon regulatory factor 3 [Source:HGNC Symbol;Acc:HGNC:6118] |
| Ensembl ID | ENSG00000126456 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 3 |
| Synonyms | C920001K05RIK, DRAFB, Ifn regulatory factor 3, IIAE7, interferon regulatory factor 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRF3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- Sumoylation motif
- nuclear export signal
- DNA binding domain
- nucleic acid binding
- IRF
- Irf binding domain
- signal response domain
- transcription activation domain
- Interferon-regulatory factor 3
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- proline rich domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- p300/cbp binding domain
- double-stranded DNA binding
- Bcl-2 homology 3 domain
- protein homodimerization
- transcription factor activity
Pathways
Biological processes and signaling networks where the IRF3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- LXR/RXR Activation
- Neuroinflammation Signaling Pathway
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- systemic lupus erythematosus
- hepatic fibrosis
- anemia
- infection
- schizophrenia
- pulmonary emphysema
- cardiac fibrosis
- organismal death
- susceptibility to acute infection-induced (herpes-specific) encephalopathy 7
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- cell death
- production in
- proliferation
- binding in
- transcription in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- cytosol
- nucleoplasm
- perinuclear space
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRF3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of type I interferon-mediated signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- signal transduction involved in regulation of gene expression
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of cytokine production involved in inflammatory response
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of interferon-alpha production
- cytoplasmic pattern recognition receptor signaling pathway
- programmed necrotic cell death
- positive regulation of interferon-beta production
- apoptotic process
- defense response to virus
- positive regulation of type I interferon production
- MDA-5 signaling pathway
- toll-like receptor 4 signaling pathway
- regulation of apoptotic process
- response to DNA damage stimulus
- immune system process
- regulation of transcription from RNA polymerase II promoter
- type I interferon-mediated signaling pathway
- cellular response to exogenous dsRNA
- innate immune response
- lipopolysaccharide-mediated signaling pathway
- regulation of inflammatory response
- macrophage apoptotic process
- TRIF-dependent toll-like receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- protein homodimerization activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding