TPGS2 Gene Summary [Human]
This gene encodes a protein that is a component of the neuronal polyglutamylase complex, which plays a role in post-translational addition of glutamate residues to C-terminal tubulin tails. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | TPGS2 |
| Official Name | tubulin polyglutamylase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:24561] |
| Ensembl ID | ENSG00000134779 |
| Bio databases IDs | |
| Aliases | tubulin polyglutamylase complex subunit 2, polyglutamylase subunit 2 |
| Synonyms | 5730437P09Rik, 5730494M16Rik, C18orf10, HMFN0601, L17, PGs2, RGD1310571, tubulin polyglutamylase complex subunit 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPGS2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMI1 / KNR4 family (SUKH-1)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPGS2 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- centriolar satellite
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding