UBR4 Gene Summary [Human]
The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | UBR4 |
| Official Name | ubiquitin protein ligase E3 component n-recognin 4 [Source:HGNC Symbol;Acc:HGNC:30313] |
| Ensembl ID | ENSG00000127481 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3 component n-recognin 4 |
| Synonyms | 1810009A16Rik, A930005E13Rik, D930005K06Rik, Gm1032, Gm1666, LOC148490, mKIAA0462, p600, RBAF600, ubiquitin protein ligase E3 component n-recognin 4, ZUBR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBR4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Putative zinc finger in N-recognin (UBR box)
- Putative zinc finger in N-recognin
- E3 ubiquitin-protein ligase UBR4 N-terminal
- calmodulin binding
- ubiquitin protein ligase activity
- E3 ubiquitin-protein ligase UBR4
- UBR-box
- enzyme
- protein binding
- E3 ubiquitin ligase domain
- Double zinc ribbon
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- renal clear cell adenocarcinoma
- renal clear cell cancer
- soft tissue sarcoma
- soft tissue sarcoma cancer
- sickle cell anemia
role in cell
- apoptosis
- formation
- accumulation in
- organization
- autophagy by
- activation in
- degradation in
- turnover in
- CSN5i-3 sensitivity
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- double-membrane vesicle
- Cytoplasm
- Plasma Membrane
- endosomes
- centrosome
- secretory granule membrane
- tertiary granule membrane
- specific granule membrane
- cytosol
- nucleoplasm
- synaptosomes
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBR4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fatty acid biosynthetic process
- positive regulation of autophagy
- proteasomal ubiquitin-dependent protein catabolic process
- protein K11-linked ubiquitination
- protein K48-linked ubiquitination
- cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process
- endosome organization
- ubiquitin-dependent protein catabolic process via the N-end rule pathway
- protein K27-linked ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- endosome
- cytoplasm
- membrane
- cytosol
- tertiary granule membrane
- plasma membrane
- specific granule membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- calmodulin binding
- zinc ion binding
- protein binding