TCN1 Gene Summary [Human]
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
Details
| Type | Retained Intron |
| Official Symbol | TCN1 |
| Official Name | transcobalamin 1 [Source:HGNC Symbol;Acc:HGNC:11652] |
| Ensembl ID | ENSG00000134827 |
| Bio databases IDs | |
| Aliases | transcobalamin 1, haptocorin, haptocorrin |
| Synonyms | Haptocorrin, HC, TC-1, TCI, transcobalamin 1, VITAMIN B12 binding |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TCN1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Eukaryotic cobalamin-binding protein
- Domain of unknown function (DUF4430)
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lung adenocarcinoma formation
- tuberculosis
- transcobalamin I deficiency
- glioblastoma
- glioblastoma cancer
- plaque psoriasis
- prostate cancer
regulates
- cyanocobalamin
- cobamamide
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- Extracellular Space
- organelle lumens
- specific granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TCN1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cobalt ion transport
- cobalamin transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- specific granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cobalamin binding