DDX31 Gene Summary [Human]
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]
Details
| Type | Retained Intron |
| Official Symbol | DDX31 |
| Official Name | DEAD-box helicase 31 [Source:HGNC Symbol;Acc:HGNC:16715] |
| Ensembl ID | ENSG00000125485 |
| Bio databases IDs | |
| Aliases | DEAD-box helicase 31, protein phosphatase 1, regulatory subunit 25 |
| Synonyms | 5830444G11, 5830444G11Rik, DEAD-box helicase 31, DEAD/H box helicase 31, Gm997, PPP1R25 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DDX31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4217)
- helicase superfamily c-terminal domain
- DEAD/DEAH box helicase
- Type III restriction enzyme, res subunit
- N-terminal helicase domain of the DEAD-box helicase superfamily
- protein binding
- DEAD-like helicases superfamily
- Helicase conserved C-terminal domain
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- Golgi Apparatus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DDX31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome biogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- Golgi apparatus
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity