OSTF1 Gene Summary [Human]
Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | OSTF1 |
| Official Name | osteoclast stimulating factor 1 [Source:HGNC Symbol;Acc:HGNC:8510] |
| Ensembl ID | ENSG00000134996 |
| Bio databases IDs | |
| Aliases | osteoclast stimulating factor 1 |
| Synonyms | bA235O14.1, Ocsf, OSF, osteoclast stimulating factor 1, SH3D3, SH3P2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OSTF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- SH3-domain binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute graft-vs-host disease
- idiopathic scoliosis
- Wegener granulomatosis
role in cell
- growth
- ossification by
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OSTF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- ossification
Cellular Component
Where in the cell the gene product is active
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding