GGN Gene Summary [Human]

This gene is a germ cell-specific gene that encodes proteins that interact with POG (proliferation of germ cells). Alternatively spliced transcript variants of a similar mouse gene encode at least three different proteins, namely gametogenetin protein 1a, gametogenetin protein 2, and gametogenetin protein 3, which show a perinuclear, cytoplasmic, and nucleolar localization, respectively. These proteins regulate the localization of POG and may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
GGN
Official Name
gametogenetin [Source:HGNC Symbol;Acc:HGNC:18869]
Ensembl ID
ENSG00000179168
Bio databases IDs NCBI: 199720 Ensembl: ENSG00000179168
Aliases gametogenetin
Synonyms AI593290, gametogenetin
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GGN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ubiquitin protein ligase binding
  • protein binding
  • nucleolar targeting motif
  • identical protein binding
  • Gametogenetin

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • spermatogenic failure 69
  • prostate cancer
regulates
role in cell
  • double-stranded DNA break repair in
  • downregulation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • perinuclear region
  • nucleoli
  • nuclear envelope

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GGN gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatogenesis
  • cell differentiation
  • gamete generation
  • double-strand break repair

Molecular Function

What the gene product does at the molecular level
  • ubiquitin protein ligase binding
  • protein binding

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