Ostf1 Gene Summary [Mouse]
Enables SH3 domain binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; peripheral nervous system ganglion; sensory organ; and urinary system. Orthologous to human OSTF1 (osteoclast stimulating factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ostf1 |
| Official Name | osteoclast stimulating factor 1 [Source:MGI Symbol;Acc:MGI:700012] |
| Ensembl ID | ENSMUSG00000024725 |
| Bio databases IDs | |
| Aliases | osteoclast stimulating factor 1 |
| Synonyms | bA235O14.1, Ocsf, OSF, osteoclast stimulating factor 1, SH3D3, SH3P2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ostf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- protein binding
- SH3-domain binding
- Ankyrin repeat
- Src Homology 3 domain superfamily
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute graft-vs-host disease
- idiopathic scoliosis
- Wegener granulomatosis
role in cell
- growth
- ossification by
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ostf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- ossification
Cellular Component
Where in the cell the gene product is active
- secretory granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding