ITPKA Gene Summary [Human]
Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.[provided by RefSeq, Apr 2011]
Details
| Type | Protein Coding |
| Official Symbol | ITPKA |
| Official Name | inositol-trisphosphate 3-kinase A [Source:HGNC Symbol;Acc:HGNC:6178] |
| Ensembl ID | ENSG00000137825 |
| Bio databases IDs | |
| Aliases | inositol-trisphosphate 3-kinase A |
| Synonyms | inositol 1,4,5-trisphosphate 3-kinase A, inositol-trisphosphate 3-kinase A, IP3-3KA, IP3KA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ITPKA often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-trisphosphate 3-kinase
- Inositol polyphosphate kinase
- enzyme binding
- calmodulin regulated protein kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- androgenic alopecia
- spinocerebellar ataxia type 7
- respiratory disorder
- infection by HIV-1
regulates
- Ca2+
- phosphatidylinositol
- myo-inositol
role in cell
- migration
- formation
- long-term potentiation
- response by
- organization
- morphogenesis
- plasticity
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoskeleton
- actin cytoskeleton
- Nucleus
- cytosol
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ITPKA gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- positive regulation of dendritic spine morphogenesis
- inositol metabolic process
- cellular response to calcium ion
- signal transduction
- response to calcium ion
- regulation of synaptic plasticity
- phosphatidylinositol phosphorylation
- dendritic spine maintenance
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- dendritic spine
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- small GTPase binding
- calmodulin-dependent protein kinase activity
- inositol tetrakisphosphate kinase activity