CAMK2B Gene Summary [Human]
The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a beta chain. It is possible that distinct isoforms of this chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | CAMK2B |
| Official Name | calcium/calmodulin dependent protein kinase II beta [Source:HGNC Symbol;Acc:HGNC:1461] |
| Ensembl ID | ENSG00000058404 |
| Bio databases IDs | |
| Aliases | calcium/calmodulin dependent protein kinase II beta, CaM-kinase II beta chain, calcium/calmodulin-dependent protein kinase type II beta chain, CaM kinase II beta subunit, proline rich calmodulin-dependent protein kinase |
| Synonyms | calcium/calmodulin-dependent protein kinase II beta, calcium/calmodulin-dependent protein kinase II, beta, Calcium/calmodulin dependent protein kinase ii delta, calcium/calmodulin-dependent protein kinase II β, calcium/calmodulin-dependent protein kinase II, β, Calcium/calmodulin dependent protein kinase ii δ, CAM2, CAMK2, Camk2 beta, Camk2 β, CAMKB, CaMKII, CAMKII beta, CAMKII β, CaM kinase II β, Ck2b, MRD54, β CaMK2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CAMK2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- calmodulin binding domain
- enzyme binding
- SnoaL-like domain
- protein binding
- Protein kinase domain
- identical protein binding
- calmodulin regulated protein kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- structural constituent of cytoskeleton
- protein homodimerization
- structural molecule
- NTF2_like
- Tyrosine kinase, catalytic domain
- calcium dependent protein serine/threonine kinase
Pathways
Biological processes and signaling networks where the CAMK2B gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Calcium Signaling
- Chemokine Signaling
- Circadian Rhythm Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Factors Promoting Cardiogenesis in Vertebrates
- Glioma Signaling
- GM-CSF Signaling
- GNRH Signaling
- HIF1α Signaling
- Melatonin Signaling
- Molecular Mechanisms of Cancer
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- Reelin Signaling in Neurons
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Serotonin Receptor Signaling
- Synaptic Long Term Potentiation
- Thrombin Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- osteoarthritis
- Alzheimer disease
- hereditary disorder
- autosomal dominant mental retardation type 54
- metabolic syndrome X
- ataxia
- mental retardation
- Huntington disease
- androgenic alopecia
role in cell
- survival
- quantity
- maturation
- signaling in
- long term synaptic depression
- thickness
- density
- plasticity
- outgrowth
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- endocytic vesicle membrane
- cell cortex
- Nucleus
- cytosol
- nucleoplasm
- dendritic spines
- sarcoplasmic reticulum membrane
- cortical actin filaments
- actin stress fibers
- filopodia
- central spindle
- perikaryon
- dendrites
- postsynaptic density
- presynaptic terminals
- actin cytoskeletal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CAMK2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of synapse maturation
- positive regulation of dendritic spine morphogenesis
- signal transduction
- nervous system development
- regulation of dendritic spine development
- protein autophosphorylation
- protein phosphorylation
- regulation of long-term neuronal synaptic plasticity
- cell differentiation
- positive regulation of neuron projection development
- regulation of calcium ion transport
- regulation of skeletal muscle adaptation
- regulation of synapse structural plasticity
- regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- calcium- and calmodulin-dependent protein kinase complex
- centrosome
- cytoplasm
- cytosol
- synapse
- neuron projection
- endocytic vesicle membrane
- sarcoplasmic reticulum membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- identical protein binding
- protein homodimerization activity
- protein binding
- actin binding
- calmodulin-dependent protein kinase activity
- calcium-dependent protein serine/threonine kinase activity