Itpka Gene Summary [Rat]
Enables calcium/calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itpka |
| Official Name | inositol-trisphosphate 3-kinase A [Source:RGD Symbol;Acc:619950] |
| Ensembl ID | ENSRNOG00000005284 |
| Bio databases IDs | |
| Aliases | inositol-trisphosphate 3-kinase A |
| Synonyms | inositol 1,4,5-trisphosphate 3-kinase A, inositol-trisphosphate 3-kinase A, IP3-3KA, IP3KA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itpka often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-trisphosphate 3-kinase
- Inositol polyphosphate kinase
- enzyme binding
- calmodulin regulated protein kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- asthma
- androgenic alopecia
- spinocerebellar ataxia type 7
- respiratory disorder
- infection by HIV-1
regulates
- Ca2+
- phosphatidylinositol
- myo-inositol
role in cell
- migration
- formation
- long-term potentiation
- response by
- organization
- morphogenesis
- plasticity
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- cytoskeleton
- actin cytoskeleton
- Nucleus
- cytosol
- dendritic spines
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itpka gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate biosynthetic process
- positive regulation of dendritic spine morphogenesis
- inositol metabolic process
- cellular response to calcium ion
- signal transduction
- response to calcium ion
- regulation of synaptic plasticity
- phosphatidylinositol phosphorylation
- dendritic spine maintenance
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytoplasm
- dendritic spine
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- inositol-1,4,5-trisphosphate 3-kinase activity
- small GTPase binding
- calmodulin-dependent protein kinase activity
- inositol tetrakisphosphate kinase activity