SHF Gene Summary [Human]
Predicted to enable phosphotyrosine residue binding activity. Predicted to be involved in apoptotic process. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SHF |
| Official Name | Src homology 2 domain containing F [Source:HGNC Symbol;Acc:HGNC:25116] |
| Ensembl ID | ENSG00000138606 |
| Bio databases IDs | |
| Aliases | Src homology 2 domain containing F |
| Synonyms | LOC108353426, RGD1562705, Src homology 2 domain containing F |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SHF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Src homology 2 (SH2) domain
Pathways
Biological processes and signaling networks where the SHF gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- glioblastoma cancer
- head and neck neoplasia
- glioblastoma
- organismal death
- atypical femur fracture
- androgenic alopecia
- early-onset high myopia
role in cell
- proliferation
- replication in
- apoptosis
- expression in
- methylation in
- binding in
- invasiveness
- tumorsphere formation by
- clonogenicity
- dimerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SHF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- apoptotic process
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding