Shf Gene Summary [Mouse]

Predicted to be involved in apoptotic process. Is expressed in several structures, including endocrine gland; large intestine; male reproductive gland or organ; nervous system; and trachea. Orthologous to human SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Apr 2025]

Details

Type
Protein Coding
Official Symbol
Shf
Official Name
Src homology 2 domain containing F [Source:MGI Symbol;Acc:MGI:3613669]
Ensembl ID
ENSMUSG00000033256
Bio databases IDs NCBI: 435684 Ensembl: ENSMUSG00000033256
Aliases Src homology 2 domain containing F
Synonyms LOC108353426, RGD1562705, Src homology 2 domain containing F
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Src homology 2 (SH2) domain

Pathways

Biological processes and signaling networks where the Shf gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • glioblastoma cancer
  • head and neck neoplasia
  • glioblastoma
  • organismal death
  • atypical femur fracture
  • androgenic alopecia
  • early-onset high myopia
regulated by
role in cell
  • proliferation
  • replication in
  • apoptosis
  • expression in
  • methylation in
  • binding in
  • invasiveness
  • tumorsphere formation by
  • clonogenicity
  • dimerization in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Shf gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • apoptotic process

Molecular Function

What the gene product does at the molecular level
  • phosphotyrosine binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.