PARVG Gene Summary [Human]
Members of the parvin family, including PARVG, are actin-binding proteins associated with focal contacts.[supplied by OMIM, Aug 2004]
Details
| Type | Processed Transcript |
| Official Symbol | PARVG |
| Official Name | parvin gamma [Source:HGNC Symbol;Acc:HGNC:14654] |
| Ensembl ID | ENSG00000138964 |
| Bio databases IDs | |
| Aliases | parvin gamma |
| Synonyms | LOC687338, Parvg (predicted), parvin gamma, parvin, gamma, parvin γ, parvin, γ |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARVG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- actin binding
- calponin homology (CH) domain superfamily
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- androgenic alopecia
- schizophrenia
- overall survival
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- cell spreading
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- focal adhesions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARVG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- cell projection assembly
- establishment or maintenance of cell polarity
- substrate adhesion-dependent cell spreading
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- focal adhesion
- cytoplasm
- actin cytoskeleton
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding