ILK Gene Summary [Human]
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Details
| Type | Protein Coding |
| Official Symbol | ILK |
| Official Name | integrin linked kinase [Source:HGNC Symbol;Acc:HGNC:6040] |
| Ensembl ID | ENSG00000166333 |
| Bio databases IDs | |
| Aliases | integrin linked kinase |
| Synonyms | ESTM24, HEL-S-28, ILK-1, ILK-2, integrin-linked kinase, P59, p59ILK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ILK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Ankyrin repeats (many copies)
- protein kinase
- phosphoinositide binding domain
- ATP binding
- Protein kinase domain
- activation loop
- Ankyrin repeat
- PAK1 phosphorylation site
- Tyrosine kinase, catalytic domain
- ankyrin repeats
- Protein kinase (unclassified specificity)
- protein kinase binding
- Protein tyrosine and serine/threonine kinase
- kinase-like domain
- paxillin-binding domain
- Ankyrin repeats (3 copies)
- protein domain specific binding
- protein binding
- magnesium ion binding
- SH3-domain binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- ankyrin binding domain
- binding protein
- Protein Kinases, catalytic domain
- integrin binding
Pathways
Biological processes and signaling networks where the ILK gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- myocardial infarction
- epithelial neoplasia
- melanoma
- neoplasia
- prostate cancer
- prostatic neoplasia
- pelvic cancer
- urogenital cancer
- abdominal cancer
role in cell
- expression in
- apoptosis
- proliferation
- signaling in
- cell death
- production in
- extension
- cell viability
- differentiation
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- high-density microsomal fractions
- low-density microsomal fraction
- detergent resistant lipid raft fraction
- cytoskeleton
- Cytoplasm
- cell periphery
- cellular membrane
- focal adhesions
- actin cytoskeleton
- cell cortex
- Nucleus
- centrosome
- Mitochondria
- costameres
- intercellular junctions
- cytosol
- basolateral cell surfaces
- nucleoplasm
- nuclear matrix
- neurites
- nerve ending
- fibrils
- actin stress fibers
- cell membrane leading edge
- chromatin
- perikaryon
- axons
- dendrites
- axon terminals
- dendritic shafts
- lamellipodia
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ILK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural precursor cell proliferation
- positive regulation of cell proliferation
- cell projection organization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- outflow tract morphogenesis
- protein phosphorylation
- positive regulation of osteoblast differentiation
- nerve development
- integrin-mediated signaling pathway
- protein kinase B signaling cascade
- myelination in peripheral nervous system
- positive regulation of transcription, DNA-dependent
- establishment or maintenance of epithelial cell apical/basal polarity
- substrate adhesion-dependent cell spreading
- negative regulation of neural precursor cell proliferation
- platelet aggregation
- positive regulation of phosphorylation
- cell-matrix adhesion
- cell morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of substrate adhesion-dependent cell spreading
- positive regulation of signal transduction
- positive regulation of BMP signaling pathway
- tumor necrosis factor-mediated signaling pathway
- branching involved in ureteric bud morphogenesis
- positive regulation of protein phosphorylation
- fibroblast migration
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- membrane
- stress fiber
- cytosol
- plasma membrane
- sarcomere
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- ATP binding
- protein binding
- protein serine/threonine kinase activity