B4GALNT3 Gene Summary [Human]
B4GALNT3 transfers N-acetylgalactosamine (GalNAc) onto glucosyl residues to form N,N-prime-diacetyllactosediamine (LacdiNAc, or LDN), a unique terminal structure of cell surface N-glycans (Ikehara et al., 2006 [PubMed 16728562]).[supplied by OMIM, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | B4GALNT3 |
| Official Name | beta-1,4-N-acetyl-galactosaminyltransferase 3 [Source:HGNC Symbol;Acc:HGNC:24137] |
| Ensembl ID | ENSG00000139044 |
| Bio databases IDs | |
| Aliases | beta-1,4-N-acetyl-galactosaminyltransferase 3 |
| Synonyms | B4GalNAcT3, beta-1,4-N-acetyl-galactosaminyl transferase 3, beta 1,4-N-ACETYLGALACTOSYLAMINYL TRANSFERASE 3, C330047A21, RGD1561056, β-1,4-N-acetyl-galactosaminyl transferase 3, β 1,4-N-ACETYLGALACTOSYLAMINYL TRANSFERASE 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human B4GALNT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acetylgalactosaminyltransferase
- PA14 domain
- N-terminal domain of galactosyltransferase
- enzyme
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human B4GALNT3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- intracellular membrane-bounded organelle
- Golgi cisterna membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- acetylgalactosaminyltransferase activity
- N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity