PCBP3 Gene Summary [Human]
This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Details
| Type | Processed Transcript |
| Official Symbol | PCBP3 |
| Official Name | poly(rC) binding protein 3 [Source:HGNC Symbol;Acc:HGNC:8651] |
| Ensembl ID | ENSG00000183570 |
| Bio databases IDs | |
| Aliases | poly(rC) binding protein 3 |
| Synonyms | ALPHA-CP3, PCBP3OT, PCBP3-OT1, Poly(rC)-binding protein 3, α-CP3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCBP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- K homology (KH) RNA-binding domain, type I
- KH domain
- single-stranded DNA binding
- protein binding
- K homology RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PCBP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- mRNA metabolic process
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mRNA binding