KRT71 Gene Summary [Human]

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]

Details

Type
Protein Coding
Official Symbol
KRT71
Official Name
keratin 71 [Source:HGNC Symbol;Acc:HGNC:28927]
Ensembl ID
ENSG00000139648
Bio databases IDs NCBI: 112802 Ensembl: ENSG00000139648
Aliases keratin 71
Synonyms CA, HYPT13, K6IRS1, keratin 71, KRT6IRS, KRT6IRS1
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KRT71 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Transforming acidic coiled-coil-containing protein (TACC), C-terminal
  • protein binding
  • Intermediate filament protein
  • Keratin type II head

Pathways

Biological processes and signaling networks where the KRT71 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • androgenic alopecia
  • hypotrichosis type 13
regulated by
  • methotrexate
regulates
role in cell
  • organization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytosol
  • keratin intermediate filaments

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KRT71 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • hair follicle morphogenesis
  • keratinization
  • intermediate filament organization

Cellular Component

Where in the cell the gene product is active
  • keratin filament
  • extracellular vesicular exosome
  • cytosol

Molecular Function

What the gene product does at the molecular level
  • structural constituent of epidermis
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.