HEXIM1 Gene Summary [Human]
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | HEXIM1 |
| Official Name | HEXIM P-TEFb complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24953] |
| Ensembl ID | ENSG00000186834 |
| Bio databases IDs | |
| Aliases | HEXIM P-TEFb complex subunit 1 |
| Synonyms | 7330426E13Rik, CLP-1, EDG1, hexamethylene bis-acetamide inducible 1, HEXIM P-TEFb complex subunit 1, HIS1, MAQ1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HEXIM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cyclin-dependent protein kinase inhibitor activity
- snRNA binding
- transcription regulator
- binding protein
- protein kinase inhibitor activity
- nuclear localization sequence
- Hexamethylene bis-acetamide-inducible protein
- protein binding
- basic domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hypoplasia
- metastasis
- fibrosis
- peripheral arterial disease
role in cell
- expression in
- apoptosis
- proliferation
- binding in
- recruitment in
- downregulation in
- differentiation
- recruitment
- cell cycle progression
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- nuclear foci
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HEXIM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- heart development
- negative regulation of transcription elongation from RNA polymerase II promoter
- activation of innate immune response
- innate immune response
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of viral transcription
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- snRNA binding
- cyclin-dependent protein kinase inhibitor activity
- protein kinase inhibitor activity