CUL4B Gene Summary [Human]
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CUL4B |
| Official Name | cullin 4B [Source:HGNC Symbol;Acc:HGNC:2555] |
| Ensembl ID | ENSG00000158290 |
| Bio databases IDs | |
| Aliases | cullin 4B |
| Synonyms | 2700050M05Rik, CULB4, cullin 4B, KIAA0695, mKIAA0695, MRSS, MRXHF2, MRXS15, MRXSC, RGD1564494, SFM2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CUL4B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- damaged DNA binding
- Cullin protein neddylation domain
- Cullin family
- protein binding
- Cullin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- cancer
- neoplasia
- tumorigenesis
- bladder cancer
- metastasis
- organismal death
- X-linked mental retardation with short stature
- growth failure
role in cell
- binding in
- apoptosis
- expression in
- proliferation
- number
- production in
- degradation in
- upregulation in
- loss
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CUL4B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astrocyte differentiation
- UV-damage excision repair
- positive regulation of G1/S transition of mitotic cell cycle
- neuron projection development
- protein polyubiquitination
- positive regulation of protein catabolic process
- ribosome biogenesis
- response to DNA damage stimulus
- ubiquitin-dependent protein catabolic process
- G1/S transition of mitotic cell cycle
- cellular response to UV
- gene expression
- protein ubiquitination
- proteasomal protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- Cul4A-RING ubiquitin ligase complex
- cytosol
- Cul4B-RING ubiquitin ligase complex
- CUL4 RING ubiquitin ligase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin protein ligase binding
- protein binding
- damaged DNA binding