SRP14 Gene Summary [Human]
Enables RNA binding activity. Involved in protein targeting to ER. Located in nucleus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SRP14 |
| Official Name | signal recognition particle 14 [Source:HGNC Symbol;Acc:HGNC:11299] |
| Ensembl ID | ENSG00000140319 |
| Bio databases IDs | |
| Aliases | signal recognition particle 14, homologous Alu RNA binding protein |
| Synonyms | ALURBP, signal recognition particle 14 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SRP14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 7S RNA binding
- Signal recognition particle 14kD protein
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SRP14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cotranslational protein targeting to membrane
- SRP-dependent cotranslational protein targeting to membrane
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
- signal recognition particle, endoplasmic reticulum targeting
Molecular Function
What the gene product does at the molecular level
- endoplasmic reticulum signal peptide binding
- protein binding
- RNA binding
- 7S RNA binding