ZBTB48 Gene Summary [Human]
Enables double-stranded telomeric DNA binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in positive regulation of transcription, DNA-templated and telomere maintenance via telomere lengthening. Located in chromosome, telomeric region. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZBTB48 |
| Official Name | zinc finger and BTB domain containing 48 [Source:HGNC Symbol;Acc:HGNC:4930] |
| Ensembl ID | ENSG00000204859 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 48, telomeric zinc finger-associated protein |
| Synonyms | 0610011D15RIK, HKR3, pp9964, TZAP, zinc finger and BTB domain containing 48, ZNF855 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZBTB48 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- nucleic acid binding
- BTB_POZ
- protein binding
- sequence-specific DNA binding
- identical protein binding
- RNA binding
- zinc finger
- double-stranded telomeric DNA binding
- zinc ion binding
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- Zinc-finger double domain
- BTB/POZ domain
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZBTB48 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription, DNA-dependent
- telomere maintenance via telomere lengthening
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- double-stranded telomeric DNA binding
- transcription regulatory region sequence-specific DNA binding