LMAN1L Gene Summary [Human]
This gene encodes a mannose-binding type 1 transmembrane protein that contains an N-terminal lectin-like carbohydrate recognition domain. The encoded protein is similar in structure to lectins found in leguminous plants. This lectin is thought to transport newly synthesized glycoproteins from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment. [provided by RefSeq, Jan 2017]
Details
| Type | Retained Intron |
| Official Symbol | LMAN1L |
| Official Name | lectin, mannose binding 1 like [Source:HGNC Symbol;Acc:HGNC:6632] |
| Ensembl ID | ENSG00000140506 |
| Bio databases IDs | |
| Aliases | lectin, mannose binding 1 like |
| Synonyms | COMPLEXIN 3, ERGIC-53L, ERGL, FLJ13993, lectin, mannose-binding 1 like, lectin, mannose-binding, 1 like, slamp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LMAN1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- legume lectins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LMAN1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER to Golgi transport vesicle
- Golgi membrane
- endoplasmic reticulum-Golgi intermediate compartment
- endoplasmic reticulum-Golgi intermediate compartment membrane
Molecular Function
What the gene product does at the molecular level
- mannose binding