SPCS1 Gene Summary [Human]
Predicted to enable peptidase activity and ribosome binding activity. Involved in viral protein processing and virion assembly. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPCS1 |
| Official Name | signal peptidase complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:23401] |
| Ensembl ID | ENSG00000114902 |
| Bio databases IDs | |
| Aliases | signal peptidase complex subunit 1, signal peptidase complex 12 kDa subunit |
| Synonyms | 1810004F21Rik, HSPC033, RGD1309125, signal peptidase complex subunit 1, signal peptidase complex subunit 1 homolog (S. cerevisiae), SPC1, SPC12, YJR010C-A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPCS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Microsomal signal peptidase 12 kDa subunit (SPC12)
- peptidase
- transmembrane domain
- ribosome binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPCS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral protein processing
- proteolysis
- virion assembly
- signal peptide processing
- protein targeting to ER
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- signal peptidase complex
Molecular Function
What the gene product does at the molecular level
- protein binding