PARN Gene Summary [Human]
The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Details
| Type | Protein Coding |
| Official Symbol | PARN |
| Official Name | poly(A)-specific ribonuclease [Source:HGNC Symbol;Acc:HGNC:8609] |
| Ensembl ID | ENSG00000140694 |
| Bio databases IDs | |
| Aliases | poly(A)-specific ribonuclease, deadenylation nuclease |
| Synonyms | 1200003I18Rik, DAN, deadenylation nuclease, DKCB6, PFBMFT4, poly(A)-specific ribonuclease, poly(A)-specific ribonuclease (deadenylation nuclease), RGD1565449 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PARN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- binding protein
- protein kinase binding
- poly(A)-specific ribonuclease
- mRNA 3' UTR binding
- R3H
- nuclease
- R3H domain
- CAF1 family ribonuclease
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- dyskeratosis congenita
- autosomal recessive dyskeratosis congenita type 6
- telomere-related pulmonary fibrosis and/or bone marrow failure type 4
- organismal death
- telomere syndrome
role in cell
- expression in
- proliferation
- cellular infiltration by
- degradation in
- maturation in
- processing in
- self-renewal capacity
- adenylation in
- oligoadenylation in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- cytosol
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PARN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- box H/ACA snoRNA 3'-end processing
- polyadenylation-dependent snoRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- RNA modification
- positive regulation of telomere maintenance via telomerase
- nuclear-transcribed mRNA poly(A) tail shortening
- miRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- protein kinase binding
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- telomeric RNA binding
- metal ion binding
- nuclease activity
- cation binding
- mRNA 3'-UTR binding