Parn Gene Summary [Mouse]
Predicted to enable several functions, including poly(A)-specific ribonuclease activity; protein kinase binding activity; and telomerase RNA binding activity. Acts upstream of or within nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in nuclear speck and nucleolus. Predicted to be active in glutamatergic synapse; nucleus; and postsynapse. Is expressed in 2-cell stage embryo; central nervous system; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 6. Orthologous to human PARN (poly(A)-specific ribonuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Parn |
| Official Name | poly(A)-specific ribonuclease (deadenylation nuclease) [Source:MGI Symbol;Acc:MGI:1921358] |
| Ensembl ID | ENSMUSG00000022685 |
| Bio databases IDs | |
| Aliases | poly(A)-specific ribonuclease (deadenylation nuclease) |
| Synonyms | 1200003I18Rik, DAN, deadenylation nuclease, DKCB6, PFBMFT4, poly(A)-specific ribonuclease, poly(A)-specific ribonuclease (deadenylation nuclease), RGD1565449 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Parn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- binding protein
- protein kinase binding
- poly(A)-specific ribonuclease
- mRNA 3' UTR binding
- R3H
- nuclease
- R3H domain
- CAF1 family ribonuclease
- enzyme
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- dyskeratosis congenita
- autosomal recessive dyskeratosis congenita type 6
- telomere-related pulmonary fibrosis and/or bone marrow failure type 4
- organismal death
- telomere syndrome
role in cell
- expression in
- proliferation
- cellular infiltration by
- degradation in
- maturation in
- processing in
- self-renewal capacity
- adenylation in
- oligoadenylation in
- generation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- postsynaptic region
- cytosol
- nucleoli
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Parn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- female gamete generation
- box H/ACA snoRNA 3'-end processing
- polyadenylation-dependent snoRNA 3'-end processing
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- RNA modification
- positive regulation of telomere maintenance via telomerase
- nuclear-transcribed mRNA poly(A) tail shortening
- miRNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleolus
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- protein kinase binding
- 3'-5'-exoribonuclease activity
- RNA binding
- protein binding
- telomeric RNA binding
- metal ion binding
- nuclease activity
- cation binding
- mRNA 3'-UTR binding