SLC13A5 Gene Summary [Human]
This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Details
| Type | Protein Coding |
| Official Symbol | SLC13A5 |
| Official Name | solute carrier family 13 member 5 [Source:HGNC Symbol;Acc:HGNC:23089] |
| Ensembl ID | ENSG00000141485 |
| Bio databases IDs | |
| Aliases | solute carrier family 13 member 5 |
| Synonyms | 1700051A21Rik, DEE25, EIEE25, INDY, mINDY, NaC2/NaCT, NACT, solute carrier family 13 member 5, SOLUTE CARRIER family 13, member 5, solute carrier family 13 (sodium-dependent citrate transporter), member 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC13A5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:dicarboxylate symporter
- ArsB_NhaD_permease
- tricarboxylic acid transporter
- protein binding
- identical protein binding
- succinate transporter
- transporter
- organic acid:sodium symporter
- citrate transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- epithelial cancer
- early infantile epileptic encephalopathy type 25
- hereditary disorder
- adult-onset obesity
- adenoid cystic carcinoma
regulated by
- cisplatin
- methotrexate
- doxorubicin
- ifosfamide
- lithium
- ESRRB
role in cell
- expression in
- growth
- phosphorylation in
- proliferation
- function
- response by
- colony formation
- cell viability
- metabolism in
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- basolateral membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC13A5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- fumarate transport
- cellular response to lithium ion
- tricarboxylic acid transmembrane transport
- transmembrane transport
- oxaloacetate transport
- sodium ion transmembrane transport
- succinate transmembrane transport
- citrate transport
- succinate transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- citrate transmembrane transporter activity
- protein binding
- succinate transmembrane transporter activity
- sodium:dicarboxylate symporter activity
- organic acid:sodium symporter activity