KLHL20 Gene Summary [Human]
The protein encoded by this gene is a member of the kelch family of proteins, which is characterized by a 44-56 amino acid repeat motif. The kelch motif appears in many different polypeptide contexts and contains multiple potential protein-protein contact sites. Members of this family are present both throughout the cell and extracellularly, with diverse activities. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | KLHL20 |
| Official Name | kelch like family member 20 [Source:HGNC Symbol;Acc:HGNC:25056] |
| Ensembl ID | ENSG00000076321 |
| Bio databases IDs | |
| Aliases | kelch like family member 20 |
| Synonyms | AB026190, D930050H05RIK, kelch-like 20, kelch-like family member 20, KELCH-LIKE protein X, KHLHX, KLEIP, KLHLX, mKIAA4210, RGD1309490 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLHL20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kelch motif
- BTB_POZ
- enzyme
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Galactose oxidase, central domain
- actin-binding domain
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- ubiquitin-protein transferase activity
- BTB/POZ domain
- interferon-gamma binding
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- mammary neoplasm
- mental retardation
- neurodevelopmental disorder
- schizophrenia
role in cell
- apoptosis
- proliferation
- migration
- degradation in
- organization
- polyubiquitination in
- ubiquitination in
- sprouting angiogenesis
- TAK-901 resistance
- JG-231 resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- actin cytoskeleton
- Golgi Apparatus
- cytosol
- trans Golgi network
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KLHL20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- cytoskeleton organization
- negative regulation of apoptotic process
- protein transport
- response to interferon-alpha
- Golgi to endosome transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- dendrite
- trans-Golgi network
- perinuclear region of cytoplasm
- PML body
- cytoplasm
- actin cytoskeleton
- cytosol
- Golgi apparatus
- Cul3-RING ubiquitin ligase complex
- axon
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- actin binding
- interferon-gamma binding