Slc13a5 Gene Summary [Mouse]
Enables citrate transmembrane transporter activity; organic acid:sodium symporter activity; and succinate transmembrane transporter activity. Involved in carboxylic acid transport and cellular response to lithium ion. Acts upstream of or within tricarboxylic acid transport. Predicted to be located in basolateral plasma membrane; cytosol; and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in brain; chondrocranium; limb; and lung. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 25. Orthologous to human SLC13A5 (solute carrier family 13 member 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc13a5 |
| Official Name | solute carrier family 13 (sodium-dependent citrate transporter), member 5 [Source:MGI Symbol;Acc:MGI:3037150] |
| Ensembl ID | ENSMUSG00000020805 |
| Bio databases IDs | |
| Aliases | solute carrier family 13 (sodium-dependent citrate transporter), member 5 |
| Synonyms | 1700051A21Rik, DEE25, EIEE25, INDY, mINDY, NaC2/NaCT, NACT, solute carrier family 13 member 5, SOLUTE CARRIER family 13, member 5, solute carrier family 13 (sodium-dependent citrate transporter), member 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc13a5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sodium:dicarboxylate symporter
- ArsB_NhaD_permease
- tricarboxylic acid transporter
- protein binding
- identical protein binding
- succinate transporter
- transporter
- organic acid:sodium symporter
- citrate transporter
- anion transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- obesity
- epithelial cancer
- early infantile epileptic encephalopathy type 25
- hereditary disorder
- adult-onset obesity
- adenoid cystic carcinoma
regulated by
- cisplatin
- methotrexate
- doxorubicin
- ifosfamide
- lithium
- ESRRB
role in cell
- expression in
- growth
- phosphorylation in
- proliferation
- function
- response by
- colony formation
- cell viability
- metabolism in
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cytosol
- basolateral membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc13a5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- alpha-ketoglutarate transport
- fumarate transport
- cellular response to lithium ion
- tricarboxylic acid transmembrane transport
- transmembrane transport
- oxaloacetate transport
- sodium ion transmembrane transport
- succinate transmembrane transport
- citrate transport
- succinate transport
Cellular Component
Where in the cell the gene product is active
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- citrate transmembrane transporter activity
- protein binding
- succinate transmembrane transporter activity
- sodium:dicarboxylate symporter activity
- organic acid:sodium symporter activity