DMRTC2 Gene Summary [Human]
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within male gamete generation and positive regulation of histone H3-K9 methylation. Predicted to be located in XY body. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | DMRTC2 |
| Official Name | DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911] |
| Ensembl ID | ENSG00000142025 |
| Bio databases IDs | |
| Aliases | DMRT like family C2 |
| Synonyms | 4933432E21Rik, Dmrt7, DMRT-like family C2, doublesex and mab-3 related transcription factor like family C2, LOC100910371 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DMRTC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Doublesex-and mab-3-related transcription factor C1 and C2
- DM DNA binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DMRTC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- sex differentiation
- spermatid nucleus elongation
- male meiosis I
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity