Dmrtc2 Gene Summary [Mouse]
Enables identical protein binding activity and sequence-specific DNA binding activity. Acts upstream of or within heterochromatin organization; male meiosis I; and spermatid nucleus elongation. Located in XY body. Is expressed in several structures, including branchial arch; genital tubercle; gonad; limb; and limb bud. Orthologous to human DMRTC2 (DMRT like family C2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dmrtc2 |
| Official Name | doublesex and mab-3 related transcription factor like family C2 [Source:MGI Symbol;Acc:MGI:1918491] |
| Ensembl ID | ENSMUSG00000011349 |
| Bio databases IDs | |
| Aliases | doublesex and mab-3 related transcription factor like family C2 |
| Synonyms | 4933432E21Rik, Dmrt7, DMRT-like family C2, doublesex and mab-3 related transcription factor like family C2, LOC100910371 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dmrtc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Doublesex-and mab-3-related transcription factor C1 and C2
- DM DNA binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- sequence-specific DNA binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- sex chromatin
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dmrtc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- sex differentiation
- spermatid nucleus elongation
- male meiosis I
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- XY body
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity