KDM2A Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least six highly degenerated leucine-rich repeats. This family member plays a role in epigenetic silencing. It nucleates at CpG islands and specifically demethylates both mono- and di-methylated lysine-36 of histone H3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Details
| Type | Protein Coding |
| Official Symbol | KDM2A |
| Official Name | lysine demethylase 2A [Source:HGNC Symbol;Acc:HGNC:13606] |
| Ensembl ID | ENSG00000173120 |
| Bio databases IDs | |
| Aliases | lysine demethylase 2A, F-box protein FBL11, jumonji C domain-containing histone demethylase 1A |
| Synonyms | 5530401A10RIK, AA589516, AW536790, CXXC8, FBL11, FBL7, F-box protein FBL7, FBXL11, Gm4560, Jhdm1, JHDM1A, lalina, LILINA, lysine demethylase 2A, lysine (K)-specific demethylase 2A, Ndy2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM2A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- F-box domain superfamily
- CTD_KDM2A_2B-like
- 2-oxoglutarate:oxygen oxidoreductase
- enzyme
- protein binding
- RmlC-like cupin superfamily
- PHD-finger
- unmethylated CpG binding
- F-box domain
- zinc ion binding
- F-box-like
- PHD finger superfamily
- histone demethylase activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- tumorigenesis
- prostatic carcinoma
- prostate cancer
- glioma
- glioma formation
- diabetic foot ulcer disorder
- angioedema
- growth failure
- neurodevelopmental disorder
role in cell
- apoptosis
- proliferation
- expression in
- activation in
- binding in
- differentiation
- breakage in
- senescence
- immortalization
- monomethylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM2A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- circadian regulation of gene expression
- protein demethylation
- negative regulation of transcription by competitive promoter binding
- regulation of circadian rhythm
- double-strand break repair via nonhomologous end joining
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- transcription cofactor activity
- unmethylated CpG binding
- histone demethylase activity
- histone demethylase activity (H3-K36 specific)