TFDP2 Gene Summary [Human]
The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | TFDP2 |
| Official Name | transcription factor Dp-2 [Source:HGNC Symbol;Acc:HGNC:11751] |
| Ensembl ID | ENSG00000114126 |
| Bio databases IDs | |
| Aliases | transcription factor Dp-2, E2F dimerization partner 2 |
| Synonyms | 1110029I05RIK, A330080J22RIK, DP2, DP-3, Tcfdp2, transcription factor Dp-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TFDP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- dimerization domain
- Dimerization domain of DP
- DNA binding domain
- nucleic acid binding
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- E2F/DP family winged-helix DNA-binding domain
- transcription factor activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- prostate cancer
- metastasis
- hereditary gingival fibromatosis
- myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis
- wheeze
- metabolic syndrome X
- chronic kidney disease
- renal cancer
role in cell
- apoptosis
- proliferation
- cell cycle progression
- invasion by
- migration
- S phase
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear envelope
- mitotic spindle
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TFDP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- negative regulation of transcription, DNA-dependent
- regulation of cell cycle
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitotic spindle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- transcription factor binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity