HCN3 Gene Summary [Human]
This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Details
| Type | Protein Coding |
| Official Symbol | HCN3 |
| Official Name | hyperpolarization activated cyclic nucleotide gated potassium channel 3 [Source:HGNC Symbol;Acc:HGNC:19183] |
| Ensembl ID | ENSG00000143630 |
| Bio databases IDs | |
| Aliases | hyperpolarization activated cyclic nucleotide gated potassium channel 3 |
| Synonyms | BCNG-4, HAC-3, Hcn4, hyperpolarization-activated, cyclic nucleotide-gated K+ 3, hyperpolarization-activated cyclic nucleotide-gated potassium channel 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HCN3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated sodium channel
- Cyclic nucleotide-binding domain
- voltage-gated potassium channel
- Ion transport protein
- Ion transport protein N-terminal
- protein binding
- ion channel
- Cyclic nucleotide-monophosphate binding domain
- CAP_ED
Pathways
Biological processes and signaling networks where the HCN3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- perikaryon
- axons
- dendrites
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HCN3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of membrane potential
- potassium ion transmembrane transport
- cellular response to cAMP
- sodium ion transmembrane transport
- regulation of membrane depolarization
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuronal cell body
- plasma membrane
- axon
- cone cell pedicle
Molecular Function
What the gene product does at the molecular level
- voltage-gated potassium channel activity
- protein binding
- cAMP binding
- voltage-gated sodium channel activity