IRF8 Gene Summary [Human]
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IRF8 |
| Official Name | interferon regulatory factor 8 [Source:HGNC Symbol;Acc:HGNC:5358] |
| Ensembl ID | ENSG00000140968 |
| Bio databases IDs | |
| Aliases | interferon regulatory factor 8 |
| Synonyms | H-ICSBP, HICSBP-1, ICSBP, ICSBP1, IMD32A, IMD32B, Interferon Consensus Sequence Binding Protein 1, interferon regulatory factor 8, Myls |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IRF8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- DNA binding domain
- nucleic acid binding
- IRF
- Irf binding domain
- Interferon-regulatory factor 3
- protein binding
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- double-stranded DNA binding
- transcription factor activity
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the IRF8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hematologic cancer
- hematological neoplasia
- cancer
- systemic lupus erythematosus
- seizures
- autosomal recessive interferon regulatory factor 8 deficiency
- experimental autoimmune uveitis
- advanced cancer
- chronic myeloid leukemia
role in cell
- formation
- binding
- expression in
- formation in
- production in
- activation in
- quantity
- apoptosis
- growth
- elimination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IRF8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- plasmacytoid dendritic cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- defense response to bacterium
- immune system process
- defense response to protozoan
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- germinal center B cell differentiation
- positive regulation of interleukin-12 production
- immune response
- follicular B cell differentiation
- cellular response to lipopolysaccharide
- autophagy
- positive regulation of interferon-gamma production
- dendritic cell differentiation
- positive regulation of apoptotic process
- phagocytosis
- myeloid cell differentiation
- cellular response to interferon-gamma
- regulation of type I interferon production
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity