PPFIA4 Gene Summary [Human]
PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPFIA4 |
| Official Name | PTPRF interacting protein alpha 4 [Source:HGNC Symbol;Acc:HGNC:9248] |
| Ensembl ID | ENSG00000143847 |
| Bio databases IDs | |
| Aliases | PTPRF interacting protein alpha 4, Liprin-alpha4 |
| Synonyms | 1110008G13Rik, C81506, Gm3812, Liprin alpha4, LOC100507405, LOC101059970, LOC685423, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4, protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), α 4, PTPRF interacting protein alpha 4, PTPRF interacting protein α 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPFIA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- SPEC
- RNase Y N-terminal region
- Ciliary protein causing Leber congenital amaurosis disease
- PspA/IM30 family
- SAM (Sterile alpha motif )
- SAM domain
- protein binding
- Laminin Domain I
- Sterile alpha motif
- Tropomyosin
- Mechanosensitive ion channel porin domain
- SAM domain (Sterile alpha motif)
- phosphatase
- liprin alpha homology domain
- Apolipoprotein A1/A4/E domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoporosis
- atrial fibrillation
- arrhythmia
- androgenic alopecia
- atrial flutter
- cardioembolic stroke
- focal cortical dysplasia of Taylor
regulates
- nickel chloride
role in cell
- survival
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cytosol
- synapse
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPFIA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synapse organization
Cellular Component
Where in the cell the gene product is active
- presynaptic active zone
- cytosol
- synapse
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding