GRIP2 Gene Summary [Human]
Predicted to enable protein C-terminus binding activity. Predicted to be involved in several processes, including neurotransmitter receptor transport, endosome to postsynaptic membrane; positive regulation of AMPA glutamate receptor clustering; and positive regulation of excitatory postsynaptic potential. Predicted to act upstream of or within Notch signaling pathway; artery smooth muscle contraction; and positive regulation of blood pressure. Predicted to be located in cytoplasm; dendritic shaft; and neuron spine. Predicted to be active in glutamatergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GRIP2 |
| Official Name | glutamate receptor interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:23841] |
| Ensembl ID | ENSG00000144596 |
| Bio databases IDs | |
| Aliases | glutamate receptor interacting protein 2 |
| Synonyms | ABP, Abpl, glutamate receptor interacting protein 2, KIAA1719 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- LXXLL motif
- canonical PDZ domain
- linker domain
- protein binding
- receptor binding
- PDZ domain
- cpPDZ_Deg_HtrA-like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- breast carcinoma
- ischemic stroke
- syndactyly
- cryptophthalmos
role in cell
- maturation
- clustering in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- postsynaptic density (PSD) fractions
- synaptosomal membrane fractions
- glutaminergic synapse
- organelle
- Cytoplasm
- cell surface
- cellular membrane
- cytoplasmic aggregates
- cytosol
- postsynaptic membrane
- dendritic spines
- neurites
- synaptosomes
- synapse
- perikaryon
- dendrites
- postsynaptic density
- dendritic shafts
- synaptosomal fractions
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Notch signaling pathway
- artery smooth muscle contraction
- positive regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- dendrite
- neuron spine
- postsynaptic membrane
- cytosol
- neuronal cell body
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glutamate receptor binding