GRIP1 Gene Summary [Human]
This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
Details
| Type | Protein Coding |
| Official Symbol | GRIP1 |
| Official Name | glutamate receptor interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:18708] |
| Ensembl ID | ENSG00000155974 |
| Bio databases IDs | |
| Aliases | glutamate receptor interacting protein 1 |
| Synonyms | 4931400F03Rik, eb, FRASRS3, glutamate receptor interacting protein 1, GRIP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AD2 domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- activation domain
- transcription regulator
- nuclear receptor domain
- AD1 domain
- beta-catenin binding
- canonical PDZ domain
- enzyme binding
- linker domain
- protein binding
- receptor binding
- PDZ domain
- basic helix loop helix/Per Arnt Sim domain
- ionotropic glutamate receptor binding
- PDZ-domain binding
- kinesin1 binding domain
- receptor binding domain
- binding protein
- cpPDZ_Deg_HtrA-like
- CBP binding domain
- cpPDZ_RseP_YlbL-like
Pathways
Biological processes and signaling networks where the GRIP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waldenström macroglobulinemia
- renal cell carcinoma
- renal cell cancer
- ischemic stroke
- Fraser syndrome type 3
- Alzheimer disease
- blistering
- shock response
- polydactyly
- plasma cell myeloma
role in cell
- activation in
- number
- density
- length
- morphogenesis
- arborization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic plasma membrane fractions
- membrane fraction
- glutaminergic synapse
- Cytoplasm
- presynaptic regions
- cell periphery
- intracellular space
- perinuclear region
- postsynaptic region
- Nucleus
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- membrane compartment
- microtubules
- granules
- cytosol
- basal cell surfaces
- presynaptic membrane
- somatic membrane
- postsynaptic membrane
- synaptic membrane
- mitochondrial outer membrane
- dendritic spines
- dendritic spine neck
- dendritic spine head
- neurites
- dendrite initial segments
- synapse
- recycling endosomes
- peri-Golgi vesicles
- rough endoplasmatic reticulum
- membrane rafts
- cellular protrusions
- perikaryon
- dendrites
- postsynaptic density
- axon terminals
- presynaptic terminals
- postsynaptic terminals
- dendritic shafts
- endoplasmic reticulum-rich vesicle fraction
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- dendrite
- postsynaptic membrane
- cytosol
- cytoplasmic vesicle
- perikaryon
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- beta-catenin binding
- receptor signaling complex scaffold activity